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Sycored (Glibenclamide)

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Sycored is a medicine used to treat type 2 diabetes mellitus. It helps control blood sugar levels and thus prevent serious complications of diabetes. It is also used to treat a menstruation-related disorder known as Polycystic ovary syndrome (PCOS) in women.

Other names for this medication:
Aviglen, Benformin, Codica, Diabetnil, Diabetrol, Diabnil, Diolin, Euglucon, Eumet, Giclamide, Glibson, Glime, Glinil, Glucomin, Glucosafe, Glucosil, Glucotrac, Glunil, Glyboral, Glybovin, Glybovine, Glycurub, Metclam, Pionorm, Secrin, Sugatrol, Symet

Similar Products:
Lipitor, Aristocort, Ambien, Clarinex, Dulcolax, Neurontin, Sovaldi, Uroxatral, Aptogrel, Plutamide, Veniz, Sidopin, Montral, Metronex,

Also known as: Glibenclamide


Sycored is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Sycored is in a class of medications called sulfonylureas. Sycored lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Sycored is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.


Usual Adult Dose for Diabetes Type 2:

Standard Sycored: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Sycored: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Sycored, micronized Sycored, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Sycored at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Sycored dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Sycored overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Sycored are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

It is very important to follow carefully any instructions from your health care team about:

  • Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.
  • Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy.
  • Travel—Keep your recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.
  • In case of emergency—There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says you have diabetes and a list of all of your medicines.
Check with your doctor right away if you start having chest pain or discomfort, nausea, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, sweating, or vomiting while you are using this medicine. These may be symptoms of a serious heart problem, including a heart attack.

Too much Sycored can cause low blood sugar (hypoglycemia) when it is used under certain conditions. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly and call someone on your health care team right away when you need advice.

Symptoms of hypoglycemia (low blood sugar) include anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache (continuing), nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness.

If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, non-diet soft drink, or sugar dissolved in water. Also, check your blood for low blood sugar. Glucagon is used in emergency situations when severe symptoms such as seizures (convulsions) or unconsciousness occur. Have a glucagon kit available, along with a syringe or needle, and know how to use it. Members of your household also should know how to use it.

Do not take this medicine if you are also using bosentan (Tracleer). Also, make sure your doctor knows about all other medicines you are using for diabetes, including insulin.

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Breastfeeding and Childhood Obesity Among African Americans: A Systematic Review. Primary in vitro antibody formation in the rat: partial characterization and properties of an inhibitor cell present in normal spleen. Barriers to accessing generic health and social care services: a qualitative study of injecting drug users. Our results suggest that dedicated risk models for valve surgery may be useful to provide more valid estimates of hospital mortality after heart valve surgery. Measurement of these parameters may also provide indices of radiation sensitivity. IHPS incidence fell from 4.4 to 1.4 per 1000 live births in Scotland between 1981 and 2004.

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The presence of correlation between the expression of the factors under study and the severity of the symptoms of intoxication in combination with the duration of the diarrhea syndrome in moderate and severe forms of Salmonella infection in children of the earliest age groups was bisoprolol and alcohol established. However, nitrate-nitrogen contamination of the groundwater was occasionally observed probably due to an excess loading of the biosolids in the past. TP53 mediates this process directly by transcriptionally modulating gene and microRNA (miRNA) expression and indirectly by regulating miRNA biogenesis. In addition to cats, numerous domestic and wild animals, including bovine, canine, human, and rodent species can serve as chronically infected reservoir hosts for various intra-erythrocytic Bartonella species. Perioperative transcranial Doppler monitoring (1) is a useful adjunct to EEG assessment of cross clamping ischaemia, providing information in real time, on MCA blood velocity deterioration that may antecede irreversible change (2) detects postoperative hyperaemic response, and (3) allows quantification of microembolic loads that, when high, have been shown to be a precursor to localised cerebral ischaemia and can be effectively treated with Dextran-40 infusion. amylovora pathogenic strains, including the recent isolates that lack plasmid pEA29 and thus cannot be detected by the previously popular PCR methods based on the detection of this plasmid. Screening with the Alcohol use Disorders Identification Test (AUDIT) in an inner-city population.

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Assessment of the fate of platelets may shed light on the underlying mechanisms leading to thrombocytopenia and may allow preventive therapies to be introduced. Recombination was studied in A-T and control human fibroblast lines by means of two recombination vectors. Partially resistant plants showed a continuous agmatine production and a weaker arginase pathway activity than the susceptible genotype. The sensitivities (Se) and specificities (Sp) were compared between Beijing and China WC references based on the evaluation of cardiovascular risk factors including hypertension, dyslipidemia, impaired fasting glucose and non-alcoholic fatty liver disease (NAFLD) in the test population being composed of 4927 school children aged 7 - 18 years. Inhibitors of human leukocyte elastase (HLE) may exert potent therapeutic effects on pulmonary emphysema, adult respiratory distress syndrome and other diseases involving tissue degradation.

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However, BP-Au NPs provided enhanced contrast for the detection of microcalcifications in both radiographically dense (PyMT) and WT mammary tissues as measured by computed tomography after intramammary delivery. Image analysis of the distribution of intraperitoneally administered fluids in patients with ovarian cancer. Effects of ammonia and norvaline on lactate metabolism by hepatocytes from starved rats. Risk factor information was obtained from interviews and from HPV viral load results. The development of communicative and narrative skills among preschoolers: lessons from forensic interviews about child abuse. In a consecutive series of 160 patients with adenocarcinoma of the ampulla of Vater, 75 (46.9 per cent) had positive lymph nodes (N1). In them were employed two study protocols that considered first and second line tests, the latter in view of recurrence of events. We evaluated the resection of the papilla of Vater performed in patients with cancer in the papilla of Vater. Irradiation of aerated solutions (0-7 Gy) led to a small increase in fluorescence intensity, but with higher doses a decrease in intensity was observed.

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