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Piosafe (Pioglitazone)

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Piosafe is a once-daily oral medication for people with type 2 diabetes. Part of the anti-diabetic drug class known as thiazolidinediones. It works by increasing the body’s sensitivity to its own insulin, allowing the hormone to work more effectively at improving blood glucose control.

Other names for this medication:
Bestoglim, Euroglip, Exerme, Glime, Glimiprime, Glita, Glito, Glizone, Glycinova, Glyciphage, Glycirest, Mepride, Mopaday, Pianorm, Pichromet, Pioglit, Piolet, Pioli, Pioriv, Piosys, Tribet, Triexer, Triopil, Ziglim, Zipio

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Colcrys, Levitra, Eriacta, Prograf, Flonase, Lexapro, Panadol, Renacardon, Rhiset, Rasmin, Simvastatinum, Truzap, Agloten,

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Also known as: Pioglitazone


Piosafe is a medication that’s used to treat type 2 diabetes. This is a condition in which where your body has a high level of glucose (sugar) in your blood. Your pancreas normally makes a hormone called insulin, which takes glucose out of your blood and helps you use the sugar as a source of energy. With type 2 diabetes, your pancreas may not be making enough insulin to remove the sugar from your blood.

And if you have type 2 diabetes, your cells may also become insulin resistant. This means that your body makes insulin but isn’t responding to it by removing the sugar from your blood. So people with type 2 diabetes have high blood sugar levels.

What Piosafe does

Piosafe works by making your cells more sensitive to insulin. The goal is for your cells to take the glucose in your blood and use it more effectively as an energy source. Because you’re using your glucose more effectively, your blood glucose levels will decrease.

This lowers your risk of serious complications of type 2 diabetes, including heart disease, nerve damage such as neuropathy, and kidney failure.

How long does it take to work?

After you start using Piosafe, it may take 7 days or longer before you notice any changes in your blood glucose level. It’s important to keep taking Piosafe every day so that it can have the best chance to work in your body.


The Piosafe dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Piosafe to treat
  • other medical conditions you may have, such as congestive heart failure (CHF)*
  • other medications that you’re taking to treat your type 2 diabetes
Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

* <em>Piosafe</em> has a<em> boxed warning</em> for CHF. This is the most serious warning from the FDA. For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

Drug forms and strengths

Piosafe comes as a tablet that you swallow, and you’ll usually take it once a day. Piosafe is available in three strengths: 15 mg, 30 mg, and 45 mg.

Dosage for type 2 diabetes

Your doctor will likely have you start taking either a 15-mg or 30-mg dose of Piosafe once a day. If needed, they may increase the dose by 15 mg for extra control of your blood sugar. The maximum dose of Piosafe is 45 mg a day.

Your starting dose will depend on if you have other health conditions, such as CHF.* And the dose will be increased over time based on how your body responds.

And in some situations where your body may be very stressed, your doctor may need to change your dose or have you stop taking Piosafe. So tell your doctor right away if you:

  • have a fever
  • have an infection
  • have had an accident
  • have just had or will have surgery
Never change your dosage of Piosafe without first talking with your doctor. And before you start taking Piosafe, be sure to tell them about any medical conditions you have or any other medications that you take. Your doctor will determine what the best dosage is for you.

* Piosafe has a boxed warning for CHF. This is the most serious warning from the Food and Drug Administration (FDA). For more information, see “FDA warning: Congestive heart failure” at the beginning of this article.

What if I miss a dose?

If you miss your dose, wait and take Piosafe when your next dose is due. Never take two doses in 1 day. If you have questions on when to take your next dose of Piosafe after you’ve missed a dose, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Piosafe is meant to be used as a long-term treatment. If you and your doctor determine that Piosafe is safe and effective for you, you’ll likely take it long term.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Piosafe are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Piosafe can interact with several other medications. It’s not known to interact with supplements or foods.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number of side effects or make them more severe.

Piosafe and other medications

Below is a list of medications that can interact with Piosafe. This list doesn’t contain all drugs that may interact with Piosafe.

Before taking Piosafe, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

Piosafe and other diabetes medications

Sometimes your doctor may prescribe Piosafe along with other medications for your type 2 diabetes, such as glyburide (DiaBeta) or insulin. However, this may put you at risk for developing hypoglycemia (low blood sugar).

Hypoglycemia can cause symptoms such as dizziness, sweating, and headache. In severe cases, you may have serious complications such as a seizure or passing out.

Before starting Piosafe treatment, it’s important to tell your doctor what other medications you’re taking.

You should also talk with your doctor about what to do if you develop symptoms of hypoglycemia, especially if you’re taking multiple diabetes medications.

Piosafe and gemfibrozil

Gemfibrozil (Lopid) may interact with Piosafe. If you’re taking gemfibrozil, the level of Piosafe in your body will rise. Gemfibrozil can also increase the amount of time that Piosafe stays in your body.

If there’s too much Piosafe in your body and you’re also taking other diabetes medications such as insulin, your blood sugar can get too low. This can cause symptoms such as dizziness or sweating.

Before you start taking Piosafe, have your doctor review your all medications. They can adjust your treatment as needed.

Piosafe and rifampin

Taking rifampin (Rimactane) along with Piosafe may decrease the level of Piosafe in your body. This means that you may not get enough Piosafe, and it may not work to treat your type 2 diabetes.

If you start or stop taking rifampin while using Piosafe, your doctor may need to change your dose of Piosafe.

Piosafe and topiramate

If you take Piosafe along with topiramate (Topamax, Trokendi XR, Qudexy XR), the level of Piosafe in your body may decrease. This means that the Piosafe may not work well to treat your type 2 diabetes.

If you’re taking topiramate and Piosafe, talk with your doctor. They may recommend changing your dose of Piosafe or monitoring your blood glucose more often to be sure that Piosafe is working for you.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Piosafe and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Piosafe. However, you should still check with your doctor or pharmacist before using any of these products while taking Piosafe.

Piosafe and foods

There aren’t any foods that have been specifically reported to interact with Piosafe. If you have any questions about eating certain foods with Piosafe, talk with your doctor.

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